Impact of Cranberry Juice Consumption on Gut and Vaginal Microbiota in Post-menopausal Women

University of Arkansas, Fayetteville

Status: Completed

Conditions: Urinary Tract Infections

Treatments: Dietary Supplement: Juice daily consumption

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT04680325

Ocean Spray

Details and patient eligibility

About

This study was a randomized, placebo-controlled, crossover, pilot dietary intervention. Ocean Spray Cranberries, Inc provided the experimental and placebo beverages, which have been validated and used in previous studies [26-29]. Both beverages were similar in appearance, taste, and aroma and assigned to volunteers according to computer-generated random orders. Both investigators and participants were blind to the assignment and products are identified by a random 3-digit code pre-printed on the cap. The participants consumed either cranberry juice or placebo beverage daily (8 fl oz per day) for 15 days

Full description

This was a prospective exploratory pilot study with a dietary intervention. Twenty-three (23) women volunteered and participated in this study. The eligibility (no menstrual period for at least 12 months) of the participants was determined using a questionnaire. The participants were postmenopausal women between the ages of 50-75 years old who met the exclusion criteria including no recent antibiotics or immunosuppressive therapies, surgery of the stomach, small or large intestines, appendectomy, gastric bypass or gastric banding in the previous 6 months, and diagnostic with any autoimmune diseases.

This study was a randomized, placebo-controlled, crossover, pilot dietary intervention. Ocean Spray Cranberries, Inc provided the experimental and placebo beverages, which have been validated and used in previous studies [26-29]. Both beverages were similar in appearance, taste, and aroma and assigned to volunteers according to computer-generated random orders. Both investigators and participants were blind to the assignment and products are identified by a random 3-digit code pre-printed on the cap. The participants consumed either cranberry juice or placebo beverage daily (8 fl oz per day) for 15 days

Enrollment: 23 patients

Sex: Female

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Post-menopausal status

Exclusion criteria

• recent (6months) antibiotics or immunosuppressive therapies
• recent (6months) abdominal surgeries

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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23 participants in 2 patient groups, including a placebo group

Placebo juice

Placebo Comparator group

Treatment:

Dietary Supplement: Juice daily consumption

Cranberry juice

Active Comparator group

Treatment:

Dietary Supplement: Juice daily consumption