Impact of CYP3A4*1G Polymorphism on Metabolism of Fentanyl in Chinese Patients Undergoing Lower Abdominal Surgery

Huazhong University of Science and Technology

Status

Completed

Conditions

Surgery

Pain

Study type

Observational

Funder types

Other

Identifiers

NCT01181492

HuazhongU

Details and patient eligibility

About

Purpose: This study aimed to investigate the impact of CYP3A4*1G genetic polymorphism on metabolism of fentanyl in Chinese patients undergoing lower abdominal surgery. Methods: 176 patients receiving elective lower abdominal surgery under general anesthesia were recruited into this study. Genotyping of CYP3A4*1G was carried out by direct sequencing. The plasma fentanyl concentration was detected 30 min after anesthesia induction by high performance liquid chromatography-ultraviolet ray (HPLC-UV). The visual analog scale (VAS) was used for pain evaluation at rest during patient-controlled analgesia (PCA) treatment 0 h, 12 h and 24 h after operation. PCA fentanyl consumption and adverse effects were recorded during the first 24 h after surgery.

Enrollment

176 patients

Sex

All

Ages

20 to 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Aged 20-65 years
Anesthesiologists (ASA) physical status I or II;
With ±20% of ideal body weight;
Received PCA administration;
Agreed to participate the research

Exclusion criteria

History of chronic pain;
Psychiatric diseases;
Diabetes mellitus;
Severe cardiovascular diseases;
Kidney or liver diseases;
Alcohol or drug abuse (according to the criteria of DSM-IV);
Pregnancy or at lactation period;
Consumed drugs (1week) or foods (3 days) known to inhibit or induce the expression of CYP3A4 enzymes prior to surgery;
Refused PCA administration;
Disagree to participate to the research