Impact of Cytomegalovirus (CMV) Replication Over Hepatitis C Recurrence in Liver Transplant Recipients (VHENUS)

Sociedad Española de Trasplante Hepático

Status: Unknown

Conditions: Hepatitis C; Cytomegalovirus Infection

Study type: Observational

Funder types: NETWORK; Industry

Identifiers

NCT01473849

VHENUS

Details and patient eligibility

About

The relationship between cytomegalovirus infection and recurrence of hepatitis C in liver transplant recipients remains controversial. Although some studies (Teixeira et al., 2000; Singh et al., 2005)have not found an association between recurrence of hepatitis C and CMV infection, studies such as Rosen et al. show that 50% of patients with CMV infection suffered cirrhosis durig follow-up period, while between not-infected patients the rate was 11%. To clarify this question, a non-interventional study will be carried out in order to assess if CMV replication is a risk factor for graft dysfunction in liver transplant recipients.

Enrollment: 179 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Men or women who underwent liver transplantation after hepatopathy caused by HCV, confirmed by pre-transplantation detection of HCV RNA
• Age > 18 years old

Exclusion criteria

• Patients co-infected with HBV or HIV
• Patients who show other causes of liver disease