Impact of Dialysis Modality on Coagulation and Platelet Function

Seoul National University

Status: Completed

Conditions: Renal Replacement Therapy

Treatments: Procedure: dialysis mode

Study type: Observational

Funder types: Other

Identifiers

NCT04512131

Dialysis mode_coagulation

Details and patient eligibility

About

The investigators will evaluate the impact of dialysis modality (intermittent hemodialysis or continuous renal replacement therapy) in coagulation and platelet function in critically ill patients

Full description

An prospective observational study will be conducted to confirm the impact of two dialysis modalitites on coagulation and platelet function in critically ill patients requiring renal replacement therapy using laboratory test, Multiplate and ROTEM.

Enrollment: 60 patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Critically ill adult patients in surgical intensive care unit who require renal replacement therapy

Exclusion criteria

• Patients treated with anti-coagulation therapy due to thrombosis/embolism
• Patients who take anti-platelet drug due to cardiac or cerebrovascular diseased
• Patients treated with pharmacological prophylaxis of deep vein thrombosis
• Patients who received blood products within 24 hours of dialysis initiation
• Patients who do not want life-sustaining care including renal replacement therapy

Trial design

60 participants in 2 patient groups

Intermittent hemodialysis

Description:

patients who are going to undergo intermittent hemodialysis or patients who are going to switch dialysis mode to intermittent hemodialysis from continuous renal replacement therapy Laboratory test including complete blood count, prothrombin time, activated partial thromboplastin time, protein C, protein S and D-dimer, EXTEM of ROTEM and Multiplate® platelet function analysis will be checked just before dialysis initiation and immediately after dialysis termination

Treatment:

Procedure: dialysis mode

continuous renal replacement therapy

Description:

patients who are going to undergo continuous renal replacement therapy Laboratory test including complete blood count, prothrombin time, activated partial thromboplastin time, protein C, protein S and D-dimer, EXTEM of ROTEM and Multiplate platelet function analysis will be checked within 24 hours after dialysis initiation and 48 hours after taking first blood sample

Treatment:

Procedure: dialysis mode