Impact of Diverticular Disease on the Detection of Colon Adenomas (DECADE)

Technical University of Munich

Status: Unknown

Conditions: Colon Adenoma; Diverticulosis

Study type: Observational

Funder types: Other

Identifiers

NCT02057562

DECADE

Details and patient eligibility

About

Benign adenomas of the colon have the potential to degenerate and become malignant. Therefore adenomatous polyps should be detected and resected during colonoscopy. Factors like advanced age and male gender are associated with the detection of adenomas. The same epidemiological pattern can be found with regard to colon diverticula. Furthermore, western world countries report higher incidences of both colorectal carcinoma as well as diverticular disease. It is not known whether a correlation exists between both entities. Some recent data have postulated higher adenoma detection rates in patients with concomitant diverticular disease (Rondagh EJ et al. Eur J Gastroenterol Hepatol. 2011; 23:1050-5. Kieff BJ et al. Am J Gastroenterol 2004; 99: 2007-11). If a positive correlation could be found this would possibly affect recommendations regarding colonoscopy surveillance intervals for patients with and without diverticular disease. The investigators therefore plan to conduct the following trial.

Enrollment: 1,000 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• indication for colonoscopy
• age >= 18 years

Exclusion criteria

• pregnant women
• patients denying written consent
• indication for colonoscopy: familial adenomatous polypose
• indication for colonoscopy: inflammatory bowel disease
• indication for colonoscopy: previously known colon polyp/adenoma/carcinoma
• history of colon surgery
• contraindication for resection of polyps
• American Society of Anesthesiologists (ASA) class IV, V or VI

Trial design

1,000 participants in 1 patient group

Routine colonoscopy

Description:

Patients receiving routine colonoscopy (for a multitude of indications) at the study centers are eligible for participation