Impact of E-cigarette Characteristics on Reinforcement and Tobacco Use Patterns

Medical University of South Carolina (MUSC)

Status: Completed

Conditions: Smoking; Tobacco Use

Treatments: Behavioral: High Concentration; Behavioral: Low Concentration; Behavioral: High Power; Behavioral: Low Power

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT03844672

K01DA047433 (U.S. NIH Grant/Contract)

00081069

Details and patient eligibility

About

The purpose of this project is to understand how different e-cigarettes influence their likeability and use among current smokers who try using e-cigarettes. Participants will receive an e-cigarette to sample over a three week period. During this time period they will complete daily electronic diaries and weekly lab visits. The results from this information will help understand how different types of e-cigarettes are likely to influence cigarette and e-cigarette use.

Enrollment: 93 patients

Sex: All

Ages: 21+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria include

• adults who have been smoking daily
• interested in using e-cigarettes
• who have a smartphone that can receive text messages and access to the internet or has an e-mail account that they check daily

Exclusion criteria include

• minimal prior e-cigarette use
• use of tobacco products other than cigarettes
• current use of cessation medications
• pregnant, trying to become pregnant, or breastfeeding,
• recent history of cardiovascular distress in the last three months (e.g., arrhythmia, heart attack, stroke, uncontrolled hypertension),
• household member currently enrolled in the study.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Double Blind

---

93 participants in 4 patient groups

Low Concentration / Low Power

Experimental group

Description:

Participant will receive an e-liquid with a low nicotine concentration and an e-cigarette with a low power for three weeks.

Treatment:

Behavioral: Low Power

Behavioral: Low Concentration

Low Concentration / High Power

Experimental group

Description:

Participant will receive an e-liquid with a low nicotine concentration and an e-cigarette with a high power for three weeks.

Treatment:

Behavioral: High Power

Behavioral: Low Concentration

High Concentration / Low Power

Experimental group

Description:

Participant will receive an e-liquid with a high nicotine concentration and an e-cigarette with a low power for three weeks.

Treatment:

Behavioral: Low Power

Behavioral: High Concentration

High Concentration / High Power

Experimental group

Description:

Participant will receive an e-liquid with a high nicotine concentration and an e-cigarette with a high power for three weeks.

Treatment:

Behavioral: High Power

Behavioral: High Concentration