Impact of E-cigarette Use on the Body

The Ohio State University

Status: Active, not recruiting

Conditions: Cigarette Smoking-Related Carcinoma

Treatments: Other: Survey Administration; Procedure: Spirometry; Procedure: Endothelial function; Procedure: Biospecimen Collection; Procedure: Oscillometry; Procedure: Nitric Oxide Breath Test

Study type: Observational

Funder types: Other

Identifiers

NCT04972513

NCI-2021-06438 (Registry Identifier)

OSU-20320

Details and patient eligibility

About

This study examines how electronic (e)-cigarette use impacts the body, by studying both users and non-users of e-cigarettes. Early evidence indicates that e-cig users experience adverse health effects. Results of this study may help policy-makers develop standards for different types of tobacco.

Full description

PRIMARY OBJECTIVE:

Examine the short-term impacts of vaping on pulmonary and respiratory outcomes.

OUTLINE:

Current e-cigarette users will vape their own e-cigarette device ad libitum for 30 minutes; non-users will watch a neutral video for 30 minutes. Before and after the 30 minute vaping [video] session, participants will undergo the following assessments: computer-based spirometry testing, nitric oxide breath testing, airwave oscillometry, and an assessment of endothelial function. Participants will also undergo collection of blood.

Enrollment: 182 patients

Sex: All

Ages: 15 to 25 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• 75 e-cig users and 75 never-users
• No self-reported diagnosis of lung disease (e.g., coronavirus disease-2019 [COVID-19], pneumonia, cystic fibrosis)
• No history of cardiac event or distress
• Not currently breastfeeding, pregnant, or planning to become pregnant (e-cig users only; will be confirmed via pregnancy test)

Trial design

182 participants in 1 patient group

Prevention (survey, breathe tests, biospecimen collection)

Description:

Participants undergo computer-based spirometry testing, nitric oxide breath testing, airwave oscillometry, and an assessment of endothelial function. Participants will undergo collection of blood. Current e-cigarette users also vape their own e-cigarette device for 30 minutes.

Treatment:

Procedure: Oscillometry

Procedure: Nitric Oxide Breath Test

Procedure: Biospecimen Collection

Procedure: Endothelial function

Procedure: Spirometry

Other: Survey Administration