Impact of Endothelial and Leukocyte Senescence in Circulatory Shock States (Seneshock)

University Hospital, Strasbourg, France

Status: Enrolling

Conditions: Infection; Shock; Cardiovascular Diseases

Treatments: Biological: Biological samples will be done to evaluate the endothelial and leukocyte senescence.

Study type: Observational

Funder types: Other

Identifiers

NCT03559569

7031

Details and patient eligibility

About

Circulatory shocks (CS) are life-threatening, acute organ dysfunction. Advances in critical care medicine have decreased early hospital mortality, increasing the number of surviving patients. Regrettably, these survivors are at increased risk of new infections but also of cardiovascular disease.

The investigators hypothesize that CS with multi-organ dysfunction is associated with premature senescence of endothelial cells and immune cells and promotes endothelial thrombogenicity and immunosenescence leading to cardiovascular disease and secondary infections.

The aim of this work is therefore to evaluate the contribution of endothelial and leucocytes senescence to the occurrence of secondary events (infectious and cardiovascular) in patients with a CS. It will provide a better understanding of the pathogenesis of cardiovascular and immune diseases following a CS, likely to guide new management strategies to prevent their occurrence.

Enrollment: 520 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Circulatory shock
• patient with health care insurance

Exclusion criteria

• Patients' refusal to participate in clinical research
• Pregnant woman
• Breastfeeding woman
• A patient with a protective order

Trial design

520 participants in 2 patient groups

Patients with circulatory shock

Description:

500 patients with circulatory shock hospitalize in ICU will be prospectively included to assess the effect of this pathology on the senescence phenotype

Treatment:

Biological: Biological samples will be done to evaluate the endothelial and leukocyte senescence.

Healthy volunteers

Description:

20 healthy volunteers will be included to assess the effect of no pathology on the senescence phenotype.

Treatment:

Biological: Biological samples will be done to evaluate the endothelial and leukocyte senescence.