Impact of Endothelial Cell Activation and Modifications of Haemostasis Induced by Infective Endocarditis on the Risk of Embolism

Public Assistance-Hospitals of Marseille (AP-HM)

Status: Completed

Conditions: Infective Endocarditis

Treatments: Other: ULTRASONOGRAPHY trans-esophageal and trans-thoracic , blood test and clinic test

Study type: Interventional

Funder types: Other

Identifiers

NCT00947817

2008-A00114-51

2008 07

Details and patient eligibility

About

Prospective study including all the consecutive patients admitted at the Department of Cardiology, Timone Hospital wih a definite diagnosis of IE according to the modified Duke criteria. The period of inclusion will be for 24 months. Eighty patients and age-matched control subject will be included. Primary end point are EE occurring during the antimicrobial treatment and secondary end points will be 6-month mortality, vegetation length and the impact of antimicrobial treatment on inflammation-induced procoagulant changes and endothelial cell activation.

Enrollment: 77 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• All the patients presenting certain diagnosis of infectious endocardite according to the criteria of modified Duke

Exclusion criteria

• Age < 18 years
• Pregnancy and feeding
• Health not allowing to give the assent
• Innate abnormalities of the haemostasis
• More than a week before the inclu antibiothérapie adapted begun

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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77 participants in 2 patient groups

patient

Experimental group

Treatment:

Other: ULTRASONOGRAPHY trans-esophageal and trans-thoracic , blood test and clinic test

control

Other group

Treatment:

Other: ULTRASONOGRAPHY trans-esophageal and trans-thoracic , blood test and clinic test