Impact of Excision Margins on Survival and Recurrence Rate in Patients With Thick Melanoma (>2mm)

Insel Gruppe AG, University Hospital Bern

Status: Completed

Conditions: Melanoma

Treatments: Procedure: surgical excision

Study type: Observational

Funder types: Other

Identifiers

NCT02088762

24-08-10

Details and patient eligibility

About

Objective: To investigated the impact of the excision of melanoma 2mm≤ in thickness with 1cm surgical margins on survival of the patients compared with 2 cm surgical margins.

Background: Early recognition and appropriate excision play a crucial role in management of malignant melanoma, while the size of surrounding normal skin that should be excised is area of controversies.

Methods: The investigators will conduct a retrospective population-based survey in patients with primary melanoma 2 mm≤ in thickness undergoing tumor excision with 1 cm and 2 cm margins in the investigators center. For both groups, the patients' charts reviewed for data including patient gender, age, tumor location, tumor type, Clark's level, Breslow thickness, tumor type, presence of ulceration, findings of sentinel nodes, local recurrences, locoregional metastases, disease free survival and overall survival were calculated for both groups.

Full description

Background

Early recognition and appropriate excision play a crucial role in management of malignant melanoma, while the size of surrounding normal skin that should be excised is area of controversies.

Objective

To investigated the impact of the excision of melanoma 2mm≤ in thickness with 1cm surgical margins on survival of the patients compared with 2 cm surgical margins.

Methods

The investigators will conduct a retrospective population-based survey in patients with primary melanoma 2 mm≤ in thickness undergoing tumor excision with 1 cm and 2 cm margins in the investigators center. For both groups, the patients' charts reviewed for data including patient gender, age, tumor location, tumor type, Clark's level, Breslow thickness, tumor type, presence of ulceration, findings of sentinel nodes, local recurrences, locoregional metastases, disease free survival and overall survival were calculated for both groups.

Enrollment: 325 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Histologically confirmed melanoma
• Safety margin 1 cm or 2 cm
• Tumor thickness according to Breslow >2mm

Exclusion Criteria

• Safety margin less 1 cm
• Unclear safety margins

Trial design

325 participants in 2 patient groups

1 cm safety margin

Description:

1 cm safety margin

Treatment:

Procedure: surgical excision

2 cm safety margin

Description:

2 cm safety margin

Treatment:

Procedure: surgical excision