Impact of Exclusive Enteral Nutrition Therapy on Sperm Quality of Patients With Crohn's Disease

Jinling Hospital, China

Status: Completed

Conditions: Crohn's Disease

Treatments: Dietary Supplement: Exclusive Enteral Nutrition Therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT02233062

NSFC (Other Identifier)

20140901

Details and patient eligibility

About

The purpose of this study is to investigate the impact of enteral nutrition therapy on sperm quality of patients with crohn's disease.

Full description

The highest age- and sex-adjusted incidence rates for Crohn's Disease (CD) occur during the peak reproductive years. In addition, gastroenterologists frequently advise and manage patients with CD who desire to conceive. Enteral nutrition therapy is effective for induction and maintenance of remission in reproductive age men with CD. However, there is no available data on the effects of enteral nutrition therapy on semen quality. The purpose of this study is to investigate the impact of enteral nutrition therapy on sperm quality of patients with CD.

Enrollment: 12 patients

Sex: Male

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of Crohn' Disease
• Male patients
• Age: 18-40 years old
• Receive 3-months exclusive enteral nutrition therapy

Exclusion criteria

• Used any experimental therapy in the 8 weeks before study entry date
• Had previously documented problems with male reproductive health, such as low sperm count, impotence, or malignancy
• The use of concomitant medication including sulphasalazine, 5-aminosalicylic acid or other immune-suppressives.
• Unable to complete the 3-months exclusive enteral nutrition therapy.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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12 participants in 1 patient group

Semen quality

Experimental group

Treatment:

Dietary Supplement: Exclusive Enteral Nutrition Therapy