Impact of Exercise on Cognitive Impairment in End-Stage Renal Disease

University of Kansas

Status: Terminated

Conditions: End-Stage Renal Disease; Cognitive Impairment

Treatments: Other: Aerobic Exercise; Procedure: Standard Care Dialysis

Study type: Interventional

Funder types: Other

Identifiers

NCT02145702

STUDY00000284

Details and patient eligibility

About

The purpose of this study is to evaluate the impact of 12 weeks of exercise on cognition in patients with end stage renal disease.

Full description

Patients with end stage renal disease have higher cognitive impairment than general population. They also have decreased physical and functional capacity. Exercise has shown to improve cognition in general population. This study will evaluate if exercise improves cognition in dialysis patients. It will also evaluate whether exercise affects performance in daily activities, mood or depression and inflammatory markers in the blood.

Enrollment: 20 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with ESRD on dialysis
• Age greater than 20 years
• Have means of transportation to and from the exercise session
• Speak English (as the neuropsychological tests will be performed in English)

Exclusion criteria

• Recent myocardial infarction (within 6 weeks), unstable angina, uncontrolled arrhythmias, congestive heart failure (> NYHA grade II)
• History of stroke in the last 2 months
• Active respiratory disease
• Uncontrolled hypertension
• Severe uncontrolled diabetes
• Persistent predialysis hyperkalemia
• Active decompensated liver disease
• Symptomatic peripheral vascular disease
• Musculoskeletal abnormalities that will be prohibit their participation in the exercise program
• Health conditions needing frequent hospitalizations
• Other health conditions causing inability to follow exercise program correctly
• Unwillingness to participate in structured exercise program
• Current use of antipsychotics or anti-epileptics
• Inability to hear, read or write which will limit their ability to perform the cognitive tests

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

Exercise Group

Experimental group

Description:

Subjects randomized to this group will start 12 weeks of supervised aerobic exercise after baseline testing.

Treatment:

Other: Aerobic Exercise

Control Group

Experimental group

Description:

Subjects randomized to this group will continue with 12 weeks of Standard Care. After 12 weeks, the subjects will cross over to the exercise arm and undergo baseline testing again and then start 12 weeks of exercise intervention.

Treatment:

Other: Aerobic Exercise

Procedure: Standard Care Dialysis