Impact of Exercise Therapy on Functional Capacity in Patients Listed for Liver Transplantation

Matthew Armstrong

Status: Completed

Conditions: Liver Cirrhosis; Liver Dysfunction

Treatments: Behavioral: Home prehabilitation program

Study type: Interventional

Funder types: Other

Identifiers

NCT02949505

QEUHB001

Details and patient eligibility

About

A UK prospective, single-centre feasibility study investigating the effects of exercise therapy on functional capacity in patients on the waiting list for liver transplantation. Patients will receive a 12-week home prehabilitation program (daily step program; functional resistance exercise sessions; telephone health call or virtual clinic). The following will be assessed at weeks 0, 6 and 12 weeks: feasibility (recruitment, compliance, safety, patients perception), functional capacity (ISWT, SPBT), psychological wellbeing (HADS questionnaire) and quality of life (EQ-5D)

Full description

as above

Enrollment: 18 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Meet the United Kingdom Liver Transplant criteria for listing
• Accepted on the liver transplant waiting list for a primary transplant
• Adults ≥18years who have an indication for a liver transplant
• Diagnosed with sarcopenia at liver transplant assessment

Exclusion criteria

• Significant cardiovascular instability including a recent Myocardial infarction, recent Cerebrovascular accident and/or a recent unstable arrhythmia
• Unstable encephalopathy - open to interpretation by the chief investigator
• Patient or next of kin non-English speaking
• Inpatients
• Refusal or lacks capacity to give informed consent

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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18 participants in 1 patient group

Intervention arm

Experimental group

Description:

12-week home prehabilitation program

Treatment:

Behavioral: Home prehabilitation program