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Impact of Exercise Training on Endothelial Function in CAD

U

University of Leipzig

Status and phase

Unknown
Phase 2

Conditions

Coronary Artery Disease

Treatments

Behavioral: Exercise Training

Study type

Interventional

Funder types

Other

Identifiers

NCT00176345
639/97
157/02

Details and patient eligibility

About

Bradykinin has been identified to contribute to the release of nitric oxide (NO), prostacyclin, and EDHF through activation of specific bradykinin 2 (B2) receptors, which is finally promoting a vasodilatory respone. Regular physical exercise training results in an improvement of endothelial function in patients with CAD. These positive effects were partially attributed to an increased expression of endothelial NO synthase (eNOS) and cyclooxygenase (COX) as a result of the training intervention.

Aim of this trial is therefore to determine, whether the training-induced correction of endothelial dysfunction is also bradykinin-dependent.

Full description

A total of 20 patients with stable coronary artery disease are prospectively randomized to 4 weeks of exercise training or sedentary lifestyle.

Endothelial function of the radial artery is determined by a high-resolution A-mode ultrasound.

Sex

Male

Ages

18 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • stable CAD
  • male gender

Exclusion criteria

  • insulin-dependent diabetes mellitus
  • significant valvular heart disease
  • smoking
  • exercise-induced myocardial ischemia
  • conditions prohibiting exercise training

Trial design

Primary purpose

Educational/Counseling/Training

Allocation

Randomized

Interventional model

Single Group Assignment

Masking

None (Open label)

Trial contacts and locations

1

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Central trial contact

Sandra Erbs, MD; Rainer P Hambrecht, MD

Data sourced from clinicaltrials.gov

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