Impact of Fluid Milk on Post-meal Glycemia and Insulinemia in Overwt/Obese Adults (S37)

Purdue University

Status: Completed

Conditions: Blood Insulin; Blood Glucose

Treatments: Other: Acute beverage (water) consumption; Other: Acute beverage (2% Milk) consumption; Other: Acute beverage (Whole Milk) consumption; Other: Acute beverage (Black Coffee) consumption; Other: Acute beverage (Skim Milk) consumption; Other: Acute beverage (Orange Juice) consumption

Study type: Interventional

Funder types: Other

Identifiers

NCT01951287

1303013430

Details and patient eligibility

About

Blood sugar and insulin levels after a meal may be altered by the food and beverages a person consumes. Keeping a healthy blood sugar level may help prevent and manage type 2 diabetes and related diseases. This study will look at how drinking different common beverages (milk, low-fat milk, nonfat milk, orange juice, coffee, and water) with a meal changes blood sugar and insulin levels.

Full description

The broad aim of the proposed research is to evaluate the effects of consuming milk and non-milk beverages with a breakfast meal on postprandial glucose and insulin responses in overweight and obese adults with varying levels of glucose tolerance (normal, pre-diabetic, type 2 diabetes). The investigators expect the consumption of fluid milk with breakfast to decrease the postprandial glucose response relative to other non-milk beverages (orange juice and sweetened coffee). Furthermore, the investigators expect that there will be no difference in the postprandial glucose or insulin response between varieties of fluid milk (skim, low-fat, and whole).

Enrollment: 54 patients

Sex: All

Ages: 35 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 35-65 years old,
• BMI between 27-40 kg/m2,
• HbA1C less than 7.5%,
• weight stable (± 4.5 kg) for the previous 3 months
• willing to consume study foods and beverages.

Exclusion criteria

• using exogenous insulin,
• currently (or within the past 6 months) following a vigorous exercise regimen, or weight loss program,
• acute illness,
• smoking,
• pregnant or planning pregnancy in the next 3 months,
• lactose intolerant,
• weight changes of greater than ± 3 kg during the study period

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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54 participants in 6 patient groups

Acute beverage (Water) consumption

Experimental group

Description:

Acute beverage (Water)consumption with breakfast measuring blood glucose and insulin levels at specific time points. consumption with breakfast measuring blood glucose and insulin levels at specific time points.

Treatment:

Other: Acute beverage (water) consumption

Acute beverage (Black Coffee) consumption

Experimental group

Description:

Acute beverage (Black Coffee)consumption with breakfast measuring blood glucose and insulin levels at specific time points. consumption with breakfast measuring blood glucose and insulin levels at specific time points

Treatment:

Other: Acute beverage (Black Coffee) consumption

Acute beverage (Orange Juice) consumption

Experimental group

Description:

Acute beverage (Orange Juice)consumption with breakfast measuring blood glucose and insulin levels at specific time points. consumption with breakfast measuring blood glucose and insulin levels at specific time points

Treatment:

Other: Acute beverage (Orange Juice) consumption

Acute beverage (Whole Milk) consumption

Experimental group

Description:

Acute beverage (Whole Milk) consumption with breakfast measuring blood glucose and insulin levels at specific time points. consumption with breakfast measuring blood glucose and insulin levels at specific time points

Treatment:

Other: Acute beverage (Whole Milk) consumption

Acute beverage (2% Milk) consumption

Experimental group

Description:

Acute beverage (2% Milk) consumption with breakfast measuring blood glucose and insulin levels at specific time points. consumption with breakfast measuring blood glucose and insulin levels at specific time points

Treatment:

Other: Acute beverage (2% Milk) consumption

Acute beverage (Skim Milk) consumption

Experimental group

Description:

Acute beverage (Skim Milk)consumption with breakfast measuring blood glucose and insulin levels at specific time points. consumption with breakfast measuring blood glucose and insulin levels at specific time points

Treatment:

Other: Acute beverage (Skim Milk) consumption