Impact of Gingival Crevicular Fluid microRNAs on Orthodontic Tooth Movement

University of Catania

Status: Completed

Conditions: Orthodontic Tooth Movement

Treatments: Device: Elastomeric powerchain

Study type: Interventional

Funder types: Other

Identifiers

NCT06023433

121-26

Details and patient eligibility

About

A split-mouth study is conducted in order to evaluate the impact of orthodontic movement on the expression of gingival crevicular fluid miRNAs related to inflammation and osteoclastogenesis during canine distalization following asymmetrical extraction treatment of upper first premolars.

Samples of gingival crevicular fluid on the mesial and distal side of the canines to be examined will be performed during the baseline and during various follow-ups.

Full description

A split-mouth study is conducted in order to evaluate the impact of orthodontic movement on the expression of gingival crevicular fluid miRNAs related to inflammation and osteoclastogenesis during canine distalization following asymmetrical extraction treatment of upper first premolars.

Orthodontic tooth movement induces bone remodeling by various signaling pathways. The variations in miRNAs expression and their impact in inflammation and osteoclastogenesis during the various stages of orthodontic tooth movements is not fully understood.

58 patients requiring asymmetrical upper first premolar extraction for orthodontic purposes have been enrolled for this split-mouth study: the canines to be distalized on the extractive site are considered as the test group, the controlateral canines (on the side without first premolar extraction) areconsidered as normal controls.

Enrollment: 27 patients

Sex: All

Ages: 11 to 18 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• patients with excellent oral hygiene throughout the study period,
• patients requiring asymmetrical maxillary first premolar extraction so monolateral canine retraction will be performed as a part of the treatment,
• patients available to come back at the clinic at the times of sample collection.

Exclusion criteria

• poor oral hygiene and/or bleeding on probing,
• use medications, steroids or other anti-inflammatory medications,
• systemic health problems or smoking.

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: Double Blind

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27 participants in 2 patient groups

Canines to be distalized

Active Comparator group

Description:

The canines need distalization after orthodontic upper first premolar asymmetrical extractions.

Treatment:

Device: Elastomeric powerchain

Controlateral canines

No Intervention group

Description:

The controlateral canines don't need distalization since the adjacent first premolars are not extracted.