Impact of Gonadotrophin REceptor Polimorphisms on the Relationship Between Serum AMH and Ovarian Response (GREPAMOR)

Instituto Valenciano de Infertilidad, IVI VALENCIA

Status: Completed

Conditions: antimüllerian Hormone and Gonadotrophin Receptor Polymorphism as Predictors of Ovarian Response

Study type: Observational

Funder types: Other

Identifiers

NCT03388099

1706-VLC-058-EB

Details and patient eligibility

About

Aim of study: To compare the relationship between serum AMH and ovarian response for IVF with the GnRH antagonist protocol in patients who are carriers of FSH and/or LH receptor polymorphisms with those that are not.

Full description

Serum AMH has shown to have a high predictive capability of the ovarian response to stimulation for IVF. On the other hand, patients who are carriers of polymorphisms in the FSH and LH receptors, have shown to need higher doses of gonadotrophins for ovarian stimulation. The proportion of carriers has been described to be around 20% of the population. Nevertheless, the determination of these polymorphisms is not performed in routine practice. It is unknown if their presence affects to the relationship between serum AMH levels and ovarian response.

This is a prospective, single center, non-interventional, cohorts study.

Enrollment: 296 patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18-45 years of age presenting to IVF clinic
• BMI of 18-35 kg/m2
• Having been tested for serum AMH with the Elecsys assay
• Being planned to undergo ovarian stimulation cycle for IVF with the GnRH antagonist protocol
• Signed written informed consent or waiver

Exclusion criteria

• Current or past disease affecting ovaries, gonadotropin or sex steroid
• Current hormone therapy

Trial design

296 participants in 2 patient groups

patients with FSH/LH polymorphisms

Description:

Infertile patients will undergo an ovarian stimulation with FSH and/or hMG. Doses will be chosen according to BMI, Antral follicle count, AMH and age.

patients without FSH/LH polymorphisms

Description:

Infertile patients will undergo an ovarian stimulation with FSH and/or hMG. Doses will be chosen according to BMI, Antral follicle count, AMH and age.