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Impact of Gut Hormones and Inflammatory Adipokines in Obese Patients Underwent Bariatric Surgery

G

Gao Zhiguang

Status

Completed

Conditions

Chronic Inflammation
Obesity
Type 2 Diabetes

Treatments

Procedure: laparoscopic sleeve gastrectomy
Procedure: laparoscopic Roux-en-Y gastric bypass

Study type

Interventional

Funder types

Other

Identifiers

NCT02963662
2014A020212219

Details and patient eligibility

About

Obesity and type 2 diabetes, dyslipidemia and related metabolic disease has become a threat to our national life and health which is showing a trend. Bariatric Surgery had been confirmed definite therapeutic effect to obesity and type 2 diabetes. However, laparoscopic gastric bypass and laparoscopic sleeve gastrectomy have the similar outcome to type 2 diabetes, but the two surgical methods and principles are completely different, which mechanisms are not yet clear. Lots of literature report adipose tissue releases adipokines and inflammatory cytokines induced chronic inflammation and obesity-related complications (insulin resistance and Type 2 diabetes).It is not clear whether to change these gastrointestinal hormones, adipokines and secretion of inflammatory cytokines with the operation, which play a therapeutic effect of obesity-related complications and diabetes. In addition, the investigators are wonder whether gut hormones, adipokines and inflammatory cytokines have some correlation in different severity obese patients,. It is worth to explore that could intestinal hormones, adipokines and inflammatory factors levels guide us to choice the different surgical approach to different severity obese patients. The investigators tried to investigate different surgical methods to alleviate diabetes and other metabolic diseases mechanisms though hormones and inflammatory factors and adipose tissue inflammation level and compare the impact of intestinal hormones and inflammatory adipokines of the two surgical approaches.

Enrollment

100 patients

Sex

All

Ages

14 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • According to the standard of obesity Obesity Task Force established in 2001, BMI≥28k / m2 with obesity-related metabolic diseases in patients, or BMI≥35kg / m2 in patients with severe obesity were selected.
  • The age of 14-65 years.
  • Self-capacity, non-drug dependence, psychological illness.
  • Not prompted stomach ulcers, erosions, tumors, polyps, atrophic gastritis and other stomach diseases in the preoperative endoscopy.
  • No history of stomach and abdominal surgery.
  • Case Source: First Affiliated Hospital of Jinan University, by the same team of doctors performed the surgical procedure.

Exclusion criteria

  • Whom did not follow the inclusion criteria

Trial design

Primary purpose

Basic Science

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

Quadruple Blind

100 participants in 3 patient groups

Roux-en-Y gastric bypass group
Experimental group
Description:
The patients undergo Roux-en-Y gastric bypass (RYGB group) following a comprehensive evaluation for the surgical indication
Treatment:
Procedure: laparoscopic Roux-en-Y gastric bypass
sleeve gastrectomy group
Experimental group
Description:
The patients undergo sleeve gastrectomy (SG group) following a comprehensive evaluation for the surgical indication
Treatment:
Procedure: laparoscopic sleeve gastrectomy
Normal BMI group
No Intervention group
Description:
no intervention

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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