Impact of Hemiplegia Due to Stroke on the Microarchitecture of the Bone

Centre Hospitalier Universitaire de Saint Etienne

Status

Terminated

Conditions

Stroke

Hemiplegia

Treatments

Procedure: MRI and 3D CT scan

Study type

Observational

Funder types

Other

Identifiers

NCT02544386

2008-A00048-47 (Other Identifier)

0701116

Details and patient eligibility

About

In hemiplegic, there is very little data on the impact of neurological deficit on the microarchitecture independent of bone mineral density and composition of the bone marrow. Rare studies have shown the relationship between some micro-architectural parameters and severity of neurological deficit. There is no study in humans on the evolution of the parameters of the microarchitecture assessed by 3D micro-tomography in the early phase of the installation of neurological deficits after stroke, in terms of a bearing bone, tibia, that a non-load bearing bones, radius.

Full description

Each patient must answer several questionnaires about their calcium intake and its ability to perform everyday tasks. They will also have 3 blood samples (15 ml each time), 3 measure of bone by 3D micro-tomography and 2 MRI examination. These examinations and sampling will take place after 30 days after stroke onset (except for MRI) and again after three months and six months after the stroke (the same day as the medical follow-up visit).

Enrollment

10 patients

Sex

All

Ages

30+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria

at least 30 years
vascular hemiplegia
National Institute of Health Stroke Score equal 4 or greater with a motor of upper limb score greater than or equal 2 and a motor score of greater than or equal legs 2

Exclusion criteria