Impact of Hepatectomy on HCC Recurrence

Anhui Medical University

Status

Completed

Conditions

Hepatocellular Carcinoma Stage I

Recurrence

Treatments

Procedure: Major hepatectomy

Study type

Observational

Funder types

Other

Identifiers

NCT06390228

2023-RE-285

No. 82172071 (Other Grant/Funding Number)

Details and patient eligibility

About

Hepatectomy is the first option for the treatment of hepatocellular carcinoma(HCC) at CNLC Ib stage. HCC patients who undergo curative hepatectomy may experience varying remnant liver volumes and thus leads to different oncological outcomes.

Full description

Patients with hepatocellular carcinoma (HCC) who undergo curative hepatectomy may experience varying remnant liver volumes. The investigators aimed to evaluate whether the extent of liver resection has an effect on postoperative recurrence in HCC patients. A retrospective analysis was conducted on 197 patients who underwent hepatectomy for a solitary HCC lesion measuring ≥5 cm between January 2019 and June 2022. Patients were divided into major hepatectomy (MAH) group (n=70) and minor hepatectomy (MIH) group (n=127) based on the extent of liver resection. Recurrence-free survival (RFS) was compared between the two groups. Propensity score matching was employed to mitigate potential biases in this research.

Enrollment

197 patients

Sex

All

Ages

18 to 85 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

histologically confirmed solitary HCC with a size of ≥5 cm
Eastern Cooperative Oncology Group score of 0 or 1
preoperative indocyanine green retention rate at 15 minutes ≤15% and Child-Pugh A classification
no evidence of vascular invasion or extrahepatic disease.

Exclusion criteria

not diagnosed with HCC or had an HCC measuring <5 cm
had confirmed tumor metastases or macrovascular invasion based on radiological examinations
died within 90 days after surgery were excluded