Impact of Hesperetin in Combination With Sucrose on Energy Metabolism

University of Vienna

Status and phase: Completed; Early Phase 1

Conditions: Blood Glucose Fluctuations; Hunger

Treatments: Other: Sucrose; Drug: Hesperetin

Study type: Interventional

Funder types: Other

Identifiers

NCT05705596

706014-2

Details and patient eligibility

About

The aim of this cross-over intervention study is to investigate the influence of the sweet-modulating substance hesperetin in combination with sucrose in comparison to an equally sweet-tasting sucrose-only solution on markers of energy metabolism.

Full description

The study is designed as a randomised cross-over intervention study with two arms. The aim is to investigate the influence of a 10% sucrose solution, corresponding to the sugar content of a conventional soft drink, compared to an equally sweet-tasting 7% sucrose solution in combination with 50 mg/L of the polyphenol hesperetin, on time-dependent blood glucose fluctuations and ad libitum energy intake in metabolically healthy male volunteers.

To investigate the underlying mechanisms, the individual appetite score, metabolic and hormonal responses to the interventions and circulating extracellular vesicles and their miRNA composition will be measured. In addition, the participants' individual thresholds for sweet taste, preference and consumption for sweet-tasting foods such as sugar and sweeteners, and their body composition will be recorded as potential influencing factors.

Enrollment: 33 patients

Sex: Male

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• male
• healthy
• non-smoking
• normal taste responses towards sweet taste

Exclusion criteria

• female
• regular smokers
• disturbed glucose and/or lipid metabolism
• regular intake of medication
• known allergies against one of the test compounds
• ageusia
• alcohol or drug addiction
• intake of antibiotics within the past 2 months

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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33 participants in 2 patient groups

Sucrose

Experimental group

Description:

10% (w/v) sucrose in water

Treatment:

Other: Sucrose

Hesperetin

Experimental group

Description:

7% (w/v) sucrose in water + 50 mg/L Hesperetin

Treatment:

Drug: Hesperetin