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Impact of Highest Drain Fluid Amylase Levels on Surgical Outcomes and Postoperative Interventions in Patients Undergoing Pancreaticoduodenectomy

Chang Gung Medical Foundation logo

Chang Gung Medical Foundation

Status

Completed

Conditions

Pancreas; Fistula

Study type

Observational

Funder types

Other

Identifiers

NCT04448795
202000980B0

Details and patient eligibility

About

This study investigated the impact of highest drain fluid amylase (DFA) level on postoperative pancreatic fistula (POPF) severity and outcomes of patients undergoing pancreaticoduodenectomy (PD) with POPF. Patient demographics of biochemical POPF and clinically relevant POPF (CR-POPF) were compared. Predictive factors were assessed using binary logistic regression. Receiver operating characteristic curve analysis was performed to determine the optimal cutoff value of highest DFA (beyond 3 days post-PD). The investigators compared length of hospital stay, surgical mortality rates, and need for postoperative interventions by highest DFA level.

Enrollment

600 patients

Sex

All

Ages

20+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • underwent PD from October 2010 to September 2018 in our institution

Exclusion criteria

  • younger than 20 years of age
  • clinical information was unavailable due to private or legal issues
  • receiving PD without pancreaticojejunostomy

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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