Impact of Hospitalization on High-sensitivity Cardiac Troponin T Concentrations Depending on Disease Severity

University of Leipzig

Status: Completed

Conditions: Non-cardiac Disease

Treatments: Diagnostic Test: Analysis of hs-cTnT serum concentration at hospitalization; Diagnostic Test: Analysis of hs-cTnT serum concentration after discharge

Study type: Observational

Funder types: Other

Identifiers

NCT04963400

RL_2021_1

Details and patient eligibility

About

We aim to examine, whether hospitalization is associated with higher high-sensitivity cardiac troponin T (hs-cTnT) serum concentrations in patients without a cardiac disease.

Full description

High-sensitivity cardiac troponin T (hs-cTnT) values will be obtained in hospitalized patients a) without a diagnosed or suspected cardiac disease, and b) with an acute medical condition that is not commonly associated with an increase of hs-cTnT concentrations. As a reference, a second sampling of blood for an analysis of the hs-cTnT serum concentration will be obtained in the same patients after discharge (60 days after hospitalization).

Enrollment: 177 patients

Sex: All

Ages: 50+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• hospitalization due to a non-cardiac disease
• age ≥ 50 years

Exclusion criteria

• diagnosed or suspected cardiac disease
• acute medical conditions commonly associated with a myocardial injury (e.g. circulatory shock, sepsis, pulmonary embolism, cerebral infarction, acute renal failure)

Trial design

177 participants in 3 patient groups

Patients with low disease severity

Description:

Hospitalized patients without a diagnosed or suspected cardiac disease and with an acute medical condition of low severity (e.g. patients with retinal detachment)

Treatment:

Diagnostic Test: Analysis of hs-cTnT serum concentration at hospitalization

Diagnostic Test: Analysis of hs-cTnT serum concentration after discharge

Patients with medium disease severity

Description:

Hospitalized patients without a diagnosed or suspected cardiac disease and with an acute medical condition of medium severity (e.g. patients with an uncomplicated acute pancreatitis oder an acute exacerbation of a chronic inflammatory bowel disease)

Treatment:

Diagnostic Test: Analysis of hs-cTnT serum concentration at hospitalization

Diagnostic Test: Analysis of hs-cTnT serum concentration after discharge

Patients with high disease severity

Description:

Hospitalized patients without a diagnosed or suspected cardiac disease and with an acute medical condition of high severity (e.g. patients with a proximal femoral fracture)

Treatment:

Diagnostic Test: Analysis of hs-cTnT serum concentration at hospitalization

Diagnostic Test: Analysis of hs-cTnT serum concentration after discharge