Impact of HPV Vaccine On The Prevalence Of HPV In Norway

University of Oslo (UIO)

Status: Completed

Conditions: Oropharyngeal Cancer; Cervical Intraepithelial Neoplasia; Cervical Cancer

Treatments: Procedure: Self sample from the oral cavity; Procedure: Self sample from vagina; Other: Questionnaire

Study type: Observational

Funder types: Other

Identifiers

NCT02934724

2014/2333

Details and patient eligibility

About

The overall aim of the study is to assess the effect of school-based Human Papillomavirus (HPV) vaccination by comparing type-specific HPV prevalence between vaccinated and non-vaccinated women born in 1997. Women born in 1997, residence to Norway in 2009 (the year of vaccine initiation of the 1997-cohort) are invited to participate in the study.

Full description

This cohort is amongst the first that was offered HPV vaccine in an organized vaccination programme globally. The women will be recruited through Facebook ads. The study will enable us to measure differences in the prevalence of HPV types in vagina and the mouth between vaccinated and non-vaccinated young women in Norway.

The womens vaccination status will be validated by linkage to the Norwegian Immunisation Registry (SYSVAK) and their residence status will be validated through linkage to the Norwegian Population Registry.

Enrollment: 315 patients

Sex: Female

Ages: 18 to 20 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Female
• Born in 1997
• Resident of Norway in 2009

Exclusion criteria

• Male
• Born before or after 1997
• Non-resident of Norway in 2009

Trial design

315 participants in 2 patient groups

Vaccinated

Description:

Women born in 1997, resident to Norway in 2009, vaccinated by the quadrivalent HPV vaccine. Interventions: * Self sample from vagina using Rover's Evalyn Brush * Self sample from the oral cavity using COPAN's FloqSwab * Questionnaire

Treatment:

Procedure: Self sample from the oral cavity

Procedure: Self sample from vagina

Other: Questionnaire

Un-vaccinated

Description:

Women born in 1997, resident to Norway in 2009, not vaccinated by the quadrivalent HPV vaccine Interventions: * Self sample from vagina using Rover's Evalyn Brush * Self sample from the oral cavity using COPAN's FloqSwab * Questionnaire

Treatment:

Procedure: Self sample from the oral cavity

Procedure: Self sample from vagina

Other: Questionnaire