Impact of Hypothalamic Gliosis on Appetite Regulation and Obesity Risk in Children

University of Washington

Status

Completed

Conditions

Obesity, Childhood

Study type

Observational

Funder types

Other

NIH

Identifiers

NCT04260048

SITE00000078

1R01DK117623-01A1 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

BEAM is a multi-site longitudinal cohort study of hypothalamic gliosis, central regulation of appetite and weight gain in children. Participants will be recruited from the community in the greater Seattle and greater Baltimore area. All participants will consent to enroll in the 24-month study during which they will complete 5 in-person study visits.

Full description

The proposed 2-site research study uses a longitudinal cohort design in 102 children aged 9-11 yr. It will include for all participants baseline MRI and functional MRI, in-depth eating behavior testing, and measurement of hormone profiles. Serial measurement of weight and self-reported eating habits will occur over 2 yr, with a repeated MRI at 2 yr. The study aims to: 1) test if MBH gliosis is associated with impaired intake regulation and poor weight outcomes over 2 yr in children, 2) determine if CNS appetitive processing is negatively affected when evidence of MBH gliosis is present, and 3) test for other brain regions in which gliosis is present in association with excess adiposity in children. An exploratory aim will assess changes in gliosis in children over 2 yr and their relation to changes in body weight and adiposity.

Enrollment

101 patients

Sex

All

Ages

9 to 11 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

9-11 y (at time of enrollment)
BMI ≥ 15th percentile for age and sex

Exclusion criteria

Significant Health conditions (e.g., type 2 diabetes)
Documented cognitive disorder
History of major weight loss of 10lbs or more, not due to illness, over the past year
Eating disorder (e.g. anorexia, bulimia)
Current use of medications known to alter appetite, body weight or brain response including: Anti-epileptics; Glucocorticoids; Antipsychotics; Stimulants for ADHD
MRI contraindication (e.g. implanted metal, claustrophobia, inability to fit in MRI scanner)
Weight >330 pounds (MRI limit)
Severe food allergies, vegetarian, or vegan, or unable to eat study foods
Currently in formal weight loss program