Impact of Infectious Diseases Specialists on the Appropriateness of Antimicrobial Therapy in Surgical and Medical Wards (ATBREFSURMED)

Henri Mondor University Hospital

Status

Completed

Conditions

Patients Receiving Antimicrobial Therapy

Treatments

Other: Infectious disease specialist advice

Study type

Interventional

Funder types

Other

Identifiers

NCT01136200

PREQHOS 08023

Details and patient eligibility

About

CONTEXT: Antibiotics are frequently used in hospital but the appropriateness of prescriptions ranged between 25-50%. The intervention of infectious disease specialists (IDS) could improve the appropriateness of prescriptions and reduce their use. The impact of IDS has not been yet fully estimated using a randomized trial to compare the quality of care of patients who will benefit of the intervention.

OBJECTIVES: To show using a randomized trial that patients with IDS advice will receive more appropriate antimicrobial therapy but less exposure to antibiotics, as compared to patients who will not receive IDS advice.

METHODS: Prospective randomized trial comparing antibiotic exposure and appropriateness of prescriptions in two groups of patients:

Control group: antibiotic prescriptions will be initiated and managed by the attending physicians
Intervention group: antibiotic prescriptions will be systematically evaluated by the IDS and changed if judged necessary by the attending physicians, following IDS' advice.

STUDY PROCESS: The study will took place in 4 university hospitals. Two medical or surgical wards will participate by hospital. For each ward, the period of the study will be 2 x 4 weeks.Total duration of the study: 12 months.

Enrollment

264 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Adults
Hospitalized in surgical or medical wards
Receiving antimicrobial therapy for active infection or prolonged surgical prophylaxis
Therapy prescribed by the attending ward physician

Exclusion criteria