Impact of Injectable Platelet Rich Fibrin Versus Low-intensity Pulsed Ultrasound on Different Orthodontic Tooth Movements During Clear Aligner Therapy

Al-Azhar University

Status: Invitation-only

Conditions: Effect of Platelet Rich Fibrin Versus Low Intensity Pulsed Ultrasound During Clear Aligner Therapy

Treatments: Device: low intensity pulsed ultrasound and iPRF

Study type: Interventional

Funder types: Other

Identifiers

NCT06276985

977/91

Details and patient eligibility

About

The aim of this prospective clinical project will be to compare the effect of platelet rich fibrin versus low- intensity pulsed ultrasound on therate of different orthodontic tooth movements during clear aligner therapy.

Full description

The aim of this prospective clinical project will be to compare the effect of platelet rich fibrin versus low- intensity pulsed ultrasound on therate of different orthodontic tooth movements during clear aligner therapy.specifically canine retraction,incsiors levellingand aliggnment,maxillary molar distalizationand incisors intrusion

Enrollment: 82 estimated patients

Sex: All

Ages: 15 to 22 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• A- leveling and alignment Eligibility criteria

1. Age ranges from 14 to 17 years. 2. Bilateral Class II molar relationship. 3. Skeletal Class I or mild Class II relationship. 4. Normal or decreased vertical height. 5. No posterior crowding or spaces. 6. Fully erupted maxillary first and second molars. 7. Congenitally missing or extracted third molars. 8. Good oral hygiene. 9. Absence of any periodontal disease and alveolar bone loss. 10. Absence of medications that may inhibit orthodontic movement

Lower incisor leveling and alignment Inclusion criteria Complete permanent dentition (third molars not included); Moderate mandibular anterior crowding (with little's irregularity index score greater than 4 mm) who required non-extraction approach in the mandibular arch; No tooth size, shape or root abnormalities visible on the patient's radiographic records; No spaces in the mandibular arch; No blocked out tooth that did not allow for placement of the bracket at the

initial bonding appointment; 6. No required management with interproximal stripping, inter-maxillary elastics, open NiTi springs, and removable or extra-oral devices. Canine retraction Eligibility criteria

Age, 15 to 25 years; Class ii division 1 malocclusion with mild or no crowding; No previous orthodontic treatment; No systemic disease that might have affected bone formation or density, such as osteoporosis, hyperparathyroidism, or vitamin d deficiency; Adequate oral hygiene; Probing depth values not exceeding 3 mm across the Entire dentition; Adequate thickness of the attached gingiva (1-2 mm); No radiographic evidence of bone loss -

Exclusion Criteria:Patients who required surgery to correct skeletal discrepancies. Patients with congenital dentoskeletal disorders. Missed or mutilated teeth in maxillary arch. Patients with poor oral hygiene and/or periodontally compromised patients Severe dental crowding that necessitates an extraction approach 2. Abnormal anteroposterior and vertical relationships; 3. Patients with cleft lip and palate, anomalies, and syndromes; 4. Previous orthodontic 5. Treatment; 6. Regular medications intake that could interfere with otm. -

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: None (Open label)

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82 participants in 14 patient groups

Experimental: Lipus side: closure of premolar extraction space

Experimental group

Description:

application of LIPUS with translation of closure of premolar extraction space that will be performed on intervention sides according to a standardized protocol

Treatment:

Device: low intensity pulsed ultrasound and iPRF

No Intervention: LIPUS side control side

No Intervention group

Description:

LIPUS side:closure of premolar extraction space control side

Experimental:iPRF side closure of premolar extraction space

Experimental group

Description:

closure ofpremolar extraction space that will be performed with iPRFapplication according to a standardized protocol

Treatment:

Device: low intensity pulsed ultrasound and iPRF

iPRF side closure of premolar extraction spacecontrol side

No Intervention group

Description:

iPRF side canine retraction control side wihout intervention

Experimental: LIPUS groupMolar distalization group inrervention side

Experimental group

Description:

distalization assisted with LIPUS according to a standardized protocol

Treatment:

Device: low intensity pulsed ultrasound and iPRF

No Intervention: LIPUS groupMolar distalization group control side

No Intervention group

Description:

distalization without LIPUS intervention

Experimental: iPRFgroup: distalization intervntion side

Experimental group

Description:

distalization will be commenced with application of iPRF according to a standardized protocol

Treatment:

Device: low intensity pulsed ultrasound and iPRF

No Intervention: iPRF group: distalization control side

No Intervention group

Description:

distalization will be commenced without application of LLLT according to a standardized protocol

Experimental: LIPUS group: leveling and alignment

Experimental group

Description:

leveling and alignment assisted with LIPUS according to a standardized protocol

Treatment:

Device: low intensity pulsed ultrasound and iPRF

Experimental: iPRF group: leveling and alignment

Experimental group

Description:

leveling and alignment be commenced with application of iPRF according to a standardized protocol

Treatment:

Device: low intensity pulsed ultrasound and iPRF

No Intervention: leveling and alignment without intervention

No Intervention group

Description:

leveling and alignment without intervention

Experimental: LIPUS group: Intrusion

Experimental group

Description:

intrusion assisted with LIPUS according to a standardized protocol

Treatment:

Device: low intensity pulsed ultrasound and iPRF

Experimental: iPRF group: Intrusion

Experimental group

Description:

intrusion assisted with application of iPRF according to a standardized protocol

Treatment:

Device: low intensity pulsed ultrasound and iPRF

No Intervention: intrusion control group

No Intervention group

Description:

intrusion without intervention