Impact of Insulin on Sympathetic Nervous System-mediated Peripheral Vasoconstriction

University of Missouri (MU)

Status and phase: Completed; Early Phase 1

Conditions: Healthy; Insulin Resistance; Vasoconstriction

Treatments: Drug: Insulin

Study type: Interventional

Funder types: Other

Identifiers

NCT05244694

2020286

Details and patient eligibility

About

The purpose of this project is to determine if hyperinsulinemia attenuates sympathetic nervous system-mediated vasoconstriction in the human leg.

Enrollment: 28 patients

Sex: All

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy adult men and women;
• 18-45 years of age;
• BMI 18-30 kg/m2;
• non-pregnant/non-breastfeeding;
• non-nicotine users;

Exclusion criteria

• taking any medications known to affect metabolic, respiratory, cardiovascular, and/or autonomic functions

Self-reported history of:

• hepatic, renal, pulmonary, cardiovascular, or neurological disease;
• stroke or neurovascular disease;
• bleeding/clotting disorders;
• sleep apnea or other sleep disorders;
• diabetes;
• smoking;
• history of alcoholism or substance abuse, excessive alcohol consumption;
• hypertension;
• active cancer;
• autoimmune disease;
• immunosuppressant therapy

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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28 participants in 1 patient group

Insulin

Experimental group

Description:

Participants will complete a 60 minute hyperinsulinemic-euglycemic infusion.

Treatment:

Drug: Insulin