Impact of Integrating Two Nano Based Irrigants With Two Activation Techniques in Treatment of Teeth With Acute Pulpitis on Postoperative Pain and Flare up Incidence

Minia University

Status: Not yet enrolling

Conditions: Postoperative Pain; Flare up; Flare Up, Symptom

Treatments: Device: ultrasonic activator; Other: Chitosan Nanoparticles Irrigant; Device: Diode Laser Activation; Other: aloe vera nanoparticles irrigant

Study type: Interventional

Funder types: Other

Identifiers

NCT07084194

EC Reaseach NO.1079

Details and patient eligibility

About

This study aimed to evaluate and compare impact of integrating passive ultrasonic activation and laser activation with nano-chitosan and aloe vera in terms of postoperative pain and flare-up incidence in a randomized clinical trial.

Enrollment: 64 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18-60 (adults only)
• multiple-rooted with multiple root canal.
• Permanent teeth with mature apex and complete root formation.
• Without root caries.
• Tooth must be restorable.
• Without anatomical abnormalities such as fusion.
• Healthy patient category I according to ASA.
• Vital tooth, with acute irreversible pulpitis and without peri-apical periodontitis.
• No periapical radiolucency.
• Consent Patients for who consent to participate and attend follow-up appointments.

Exclusion criteria

• single root canals or double root.
• Root canal calcifications.
• Root resorption or fracture.
• Previously root canal treated teeth.
• immunocompromised patients.
• Pregnant females
• Patients with systemic diseases as diabetic or hypertension patients.
• Patients with facial swelling.
• patients who use analgesics or antibiotics within 48-72 hours.
• Allergy to any materials used (e.g., irrigants or anesthetics).
• psychiatric illness
• Teeth that are not indicated for endodontic treatment: bad oral hygiene, mobile teeth, or recessed teeth.
• Previously endodontically treated teeth.
• Teeth with sinus tract.

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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64 participants in 4 patient groups

GROUP I

Experimental group

Description:

treated with nanochitosan and passive ultrasonic activation

Treatment:

Other: Chitosan Nanoparticles Irrigant

Device: ultrasonic activator

GROUP II

Experimental group

Description:

treated with nanochitosan and laser activation

Treatment:

Device: Diode Laser Activation

Other: Chitosan Nanoparticles Irrigant

GROUP III

Experimental group

Description:

treated with nano-Aloe Vera and passive ultrasonic activation

Treatment:

Other: aloe vera nanoparticles irrigant

Device: ultrasonic activator

GROUP IV

Experimental group

Description:

treated with nano-Aloe Vera and laser activation

Treatment:

Other: aloe vera nanoparticles irrigant

Device: Diode Laser Activation