Impact of Intensive Exercise Training on Coronary Collateral Circulation in Patients With Stable CAD

University of Leipzig

Status: Completed

Conditions: Stable Coronary Artery Disease

Treatments: Behavioral: exercise training; Behavioral: Intensive exercise training

Study type: Interventional

Funder types: Other

Identifiers

NCT01209637

SMW 04

Details and patient eligibility

About

Exercise training in patients with coronary artery disease is able to correct several risk factors. Furthermore endothelial function can be improved.

There are some hinds for improved collateral circulation after exercise training, nevertheless there is no study showing significant improvement/ increase in coronary collaterals. This might be due to technique of collateral measurement. Therefore we conduct a study were coronary blod flow before and after 4 weeks of exercise training were measured.

Enrollment: 60 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• stable CAD
• min.1 coronary artery stenosis >50%
• patient is symptomatic ( CCS 1-3)or has documented myocardial ischemia during stress test
• angina threshold >75 Watt
• informed consent

Exclusion criteria

• Age <18 oder >75
• akut coronary syndrome within 2 weeks
• LV-EF < 40 %
• significant valve diseases
• reduced patient compliance
• muscular disorder
• bronchial asthma or COLD stadium III and IV

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 3 patient groups

control

No Intervention group

Description:

standard care of coronary artery diseases incl. recommended home based exercise 3x/week

Exercise training

Active Comparator group

Description:

exercise training for 4 weeks at 70% of ischemia free individual threshold within a rehabilitation care center

Treatment:

Behavioral: exercise training

intensive exercise training

Active Comparator group

Description:

intensive exercise training incl. interval training

Treatment:

Behavioral: Intensive exercise training