Impact of Intensive Outpatient Rehabilitation on Non-Motor Patient-Reported Outcomes in Parkinson's Disease (INTENSO)

Università Politecnica delle Marche

Status: Completed

Conditions: Parkinson Disease

Treatments: Other: Multimodal rehabilitation training at low intensity; Other: Multimodal rehabilitation training at high intensity

Study type: Observational

Funder types: Other

Identifiers

NCT06695286

ID 101/2024, number 3054

Details and patient eligibility

About

This historical cohort study aims to evaluate the impact of different intensity rehabilitation protocols on the short and medium-term severity of non-motor symptoms in patients with Parkinson's Disease. One of the principal strengths of this study is that it is a real-life study, so it has a high external validity necessary to test the clinical effectiveness of these two types of training, which could have significant practical implications for rehabilitation in Parkinson's disease.

Enrollment: 48 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adults diagnosed with Idiopathic PD, Hoehn & Yahr stage ≥ 1 < 5, consecutive referral to the rehabilitation facility between 1 January 2014 and 31 December 2019 to receive outpatient physiotherapy treatment for the management of motor disability, specifically targeting gait, balance, or posture disorders;
• completion of the course of rehabilitation treatment;
• availability of Non-Motor Symptom Scale and Unified Parkinson's Disease Rating Scale, recorded before and after treatment and 6 plus or minus 1 months later

Exclusion criteria

• diagnosis of any primary or secondary parkinsonism rather than PD
• symptom onset since less than three years
• any concomitant neurological disease (e.g. polyneuropathy, stroke, etc)
• any other chronically disabling disease (e.g. severe heart, liver or kidney failure, cancer, psychiatric disorders, limb amputation, severe musculoskeletal or neuropathic pain)
• changes in antiparkinsonian drug therapy during the whole study period
• exposure to a course of physiotherapy during the 6 months preceding the study

Trial design

48 participants in 1 patient group

People with Parkinson's Disease consecutively referred to the outpatient rehabilitation facility

Description:

Single center historical cohort study of people with PD consecutively referred to the outpatient rehabilitation facility of a Center for Diagnosis and Treatment of Movement Disorders, based in a university hospital in Italy.

Treatment:

Other: Multimodal rehabilitation training at high intensity

Other: Multimodal rehabilitation training at low intensity