Impact of Intermittent Hypoxia on the Function of the Phagocytes

Taipei Veterans General Hospital

Status: Unknown

Conditions: Obstructive Sleep Apnea of Adult

Study type: Observational

Funder types: Other

Identifiers

NCT03618719

2016-06-005CC

Details and patient eligibility

About

Patients with treatment-naive obstructive sleep apnea (OSA) who need continuous positive airway pressure (CPAP) therapy on clinical basis are included as well as healthy controls without OSA. 15 cc peripheral venous blood is drawn on the date of diagnosis of OSA and 3-6 months after CPAP therapy. Granulocytes are harvested and tested for its function, such as phagocytosis, reactive oxygen species (ROS) production and bacteria-killing ability.

Full description

Patients with treatment-naive obstructive sleep apnea (OSA) who need continuous positive airway pressure (CPAP) therapy on clinical basis are included. Healthy controls without OSA are enrolled, too. 15 cc peripheral venous blood is drawn on the date of diagnosis of OSA and 3-6 months after CPAP therapy (not given to controls). Granulocytes are harvested and tested for its function, such as phagocytosis, reactive oxygen species (ROS) production and bacteria-killing ability.

Enrollment: 40 estimated patients

Sex: All

Ages: 20+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

<OSA group> 1. Patients with treatment-naive obstructive sleep apnea (OSA) who need continuous positive airway pressure (CPAP) therapy on clinical basis 2. aged 20 years or older 3. Apnea-hypopnea index (AHI) at least 15/hour 4. Willing to participate this study <Control group>

1. Healthy controls without OSA
2. aged 20 years or older
3. AHI less than 5/hour

Exclusion criteria

<OSA group>

1. OSA patients who do not need continuous positive airway pressure (CPAP) therapy

2. OSA Patients have ever received CPAP or other treatment

3. aged less than 20 years

4. AHI at least 15/hour

5. Not willing to participate this study <Control group>

6. Apnea-hypopnea index (AHI) equals to or more than 5/hour 2. aged less than 20 years 3. Not willing to participate this study

Trial design

40 participants in 2 patient groups

Obstructive sleep apnea

Description:

Patients with treatment-naive obstructive sleep apnea (OSA) who need continuous positive airway pressure (CPAP) therapy on clinical basis

Control

Description:

Healthy controls without OSA