Impact of iv Dexamethasone on Reversal of Rocuronium-induced Neuromuscular Block by Sugammadex

Vaud University Hospital Center

Status and phase: Withdrawn; Phase 4

Conditions: Neuromuscular Blockade

Treatments: Drug: IV dexamethasone; Drug: Normal saline

Study type: Interventional

Funder types: Other

Identifiers

NCT02562417

CER 478/14

Details and patient eligibility

About

Sugammadex is used as a reversal drug for rocuronium- or vecuronium-induced neuromuscular block during general anaesthesia. IV dexamethasone is injected as a prophylactic measure against postoperative nausea and vomiting. Recent animal data have shown that dexamethasone may impair the reversal effect of sugammadex. The objective of this randomised controlled trial is to confirm in the clinical practice these preliminary results.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients scheduled to undergo microlaryngoscopy and ear-nose-throat endoscopic procedures

Exclusion criteria

• contraindication to dexamethasone administration
• contraindication to sugammadex administration
• contraindication to rocuronium administration

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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0 participants in 2 patient groups, including a placebo group

No IV dexamethasone

Placebo Comparator group

Description:

Patients will receive an equivalent volume of normal saline.

Treatment:

Drug: Normal saline

IV dexamethasone

Experimental group

Description:

Patients will receive 0.1 mg/kg of dexamethasone.

Treatment:

Drug: IV dexamethasone