IMPACT OF KIDNEY FAILURE ON THE REGULATION OF HUMORAL RESPONSE TO VACCINATION (Tfh-CKD)

Institute of Hospitalization and Scientific Care (IRCCS)

Status

Not yet enrolling

Conditions

Vaccine Response

Chronic Kidney Disease Requiring Chronic Dialysis

Treatments

Biological: Influenza vaccination

Biological: SARS-CoV-2 vaccine

Study type

Observational

Funder types

Other

Identifiers

NCT06635525

5281

Details and patient eligibility

About

The aim of this observational study is to determine if and how kidney failure affects the development of protective immune responses following vaccination in patients on chronic dialysis.

Researchers will compare the effectiveness of the influenza vaccine in inducing protective antibodies between hemodialysis patients and subjects without chronic kidney disease.

Participants will:

Be enrolled at the time of influenza vaccination
Visit the clinic at 7, 14, 30, 60, and 120 days after vaccination
Be asked to provide relevant clinical information and a blood sample at each visit

Enrollment

146 estimated patients

Sex

All

Ages

18 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age between 18 and 70 years
Patients undergoing thrice-weekly hemodialysis / peritoneal dialysis for at least 3 months OR healthy individuals without a history of renal insufficiency
Subjects eligible to receive a seasonal influenza vaccine
Signed informed consent for participation in the study

Exclusion criteria

Recent influenza infection (clinically resolved less than 3 months ago).
Administration of immunosuppressive drugs in the two weeks prior to vaccination.
Administration of another vaccine in the three weeks prior to enrollment (co-administration of other vaccines with those under study does not contraindicate participation).
Systemic infection clinically resolved less than two weeks before enrollment.