Impact of Life Events and Psychological Stress in Rheumatoid Arthritis Set-up : Case-control Study Within a Multifactorial and Integrative Psychological Model (Stress-PR)

University Hospital of Bordeaux

Status

Completed

Conditions

Stress Disorder

Arthritis, Rheumatoid

Treatments

Behavioral: Questionnaire

Biological: blood sample

Study type

Observational

Funder types

Other

Identifiers

NCT03550833

CHUBX 2018/01

Details and patient eligibility

About

Rheumatoid Arthritis (RA) is an inflammatory rheumatic disease that can lead to structural damage and handicap. The RA physiopathology is multifactorial, including genetic and environmental risk factors. The identification of environmental factors implication is crucial to understand the RA mechanism, and improves the diagnosis and the treatment of the disease.

Full description

The physiopathology of RA is multifactorial, implicating genetic and environmental factors. Within the environmental factors, the exact role of psychological stress and life events on the onset of the disease is still under question. In clinical practice, patients usually report the occurrence of a stressing life event before the diagnosis of the disease (mourning, dismissal, divorce...). Nevertheless, literature reviews present some discrepancies and did not lead to a clear identification of the role of psychological stress in RA onset. This is mainly due to the evaluation methods of stress within those previous studies, considering stress as a unique response of the organism without taking into account personal, sociological, biological or environmental history. The aim of the study is to analyze the impact of stress on the RA onset within an integrative model, to evaluate patient assessment of the stress, and to present strategies to fix it.

Enrollment

152 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Patients RA :

Inclusion Criteria:

patients aged over 18 years old
patients affected by RA according to ACR/EULAR 2010 criteria, with a disease duration less than 2 years.
Speaking and understanding French language
Being informed about the study and having given his oral consent

Exclusion Criteria:

Pregnant or breastfeeding women
Patient who refuse to participate.

Control :

Inclusion Criteria:

patients aged over 18 years old
patients with a visceral surgery for less than 2 years (appendectomy, cholecystectomy, bowel obstruction, hernia, eventration...)
Speaking and understanding French language
Being informed about the study and having given his oral consent

Exclusion Criteria: