Impact of Maternal Xylitol Consumption on Mutans Sterptococci

King Abdulaziz University

Status and phase: Completed; Phase 4

Conditions: Dental Caries and Streptococcus Mutans Count

Treatments: Drug: fluoride varnish application; Drug: xylitol

Study type: Interventional

Funder types: Other

Identifiers

NCT02036151

KAU

Details and patient eligibility

About

The study was designed to determine whether maternal xylitol consumption through regular chewing of xylitol gums can affect the salivary mutans streptococci (MS), dental caries, and dental plaque levels of their children.

Full description

Method: Study sample included 60 mother and child pairs with high salivary mutans streptococcus (MS) levels. Samples were randomly divided into experimental group (30 pairs) and control group (30 pairs). Mothers in the experimental group received xylitol chewing gum treatment three times/day for three months, whereas the controls received fluoride varnish. Both groups received oral hygiene instructions, dietary counseling and restorative treatment. All children were examined after 6, 12 and 18 months from the initiation of the study to assess caries, plaque and salivary mutans streptococcus (MS) levels.

Enrollment: 60 patients

Sex: All

Ages: 10 to 36 months old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• mothers with high salivary counts (≥ 105)
• mothers having children at least 10 months of age (10-36months) or having a minimal of 8 primary teeth.

Exclusion criteria

• subjects with systemic disorders or on regular medications

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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60 participants in 2 patient groups

Experimental, control

Experimental group

Description:

Mothers in the experimental group were instructed to chew 1 pellet of xylitol gum (Fennobon Oy, Yrittäjäntie, Finneland -gum, 3 times ) for a period of 3 months. control mothers did not receive any medications. All mothers received oral hygiene instructions and restorative treatment when needed. Offspring of both the experimental and control groups did not receive any medication and were followed for at 6,12, 18 and 24 month from initiation of mothers consumption. month

Treatment:

Drug: xylitol

fluoride varnish application

Active Comparator group

Description:

The control group participated in a preventive program under the supervision of the Pediatric Dentistry Department. The program activities consisted of oral hygiene instructions, fluoride varnish application (Duraphat 5% Na F ,Ultradent Products, Utah, USA) and restorative treatment when needed.

Treatment:

Drug: fluoride varnish application