Impact of Naloxone on the Analgesic Effect of Paracetamol in Healthy Volunteers

University Hospital, Clermont-Ferrand

Status and phase: Completed; Phase 1

Conditions: Pain

Treatments: Drug: Naloxone and paracetamol

Study type: Interventional

Funder types: Other

Identifiers

NCT00750048

CHU-0036

Details and patient eligibility

About

The aim of this study is to check if Naloxone induce an inhibiting effect on the analgesic effect of paracetamol in healthy volunteer, using evoked potentials.

Full description

Double Blind, cross-over study in healthy volunteers.

Enrollment: 12 patients

Sex: Male

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy men
• between 18 and 40 years old
• written consent given

Exclusion criteria

• Naloxone or paracetamol hypersensibility
• Excessive consumption of alcohol, tobacco, coffee, tea or toxicomania
• Concomitant medication

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind