Impact of nCPAP Treatment on Liver Function in Patients With Sleep Apnea Syndrome and Nonalcoholic Steatohepatitis

University Hospital, Angers

Status: Unknown

Conditions: Sleep Apnea Syndrome; Nonalcoholic Steatohepatitis

Treatments: Device: nCPAP

Study type: Interventional

Funder types: Other

Identifiers

NCT00152711

PHRC 03-07

Details and patient eligibility

About

This study aims to evaluate the impact of nasal continuous positive airway pressure (nCPAP) treatment on liver enzymes in patients with sleep apnea syndrome and nonalcoholic steatohepatitis. Using a cross over design, the evolution of liver enzymes will be evaluated in 40 patients during a consecutive period of 6 weeks, with and without nCPAP treatment.

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18 to 70 years old
• Nonalcoholic steatohepatitis proven by liver biopsy
• Sleep apnea syndrome proven by polysomnography with an apnea-hypopnea index > 10 events/hour
• Informed consent

Exclusion criteria

• Psychiatric disorder
• Other cause of liver disease
• Professional driver

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)