Impact of Netrin-1 in the Pathophysiology of Placenta Accreta Spectrum

Assiut University

Status: Completed

Conditions: Pathophysiology of Placenta Accreta

Treatments: Other: no intervention applied

Study type: Observational

Funder types: Other

Identifiers

NCT04628169

netrin-1 in placenta accreta

Details and patient eligibility

About

The main goal of this study is to assess the role of Netrin 1, neogenin and ZEB1 in PAS-associated invasion

Full description

• To evaluate the immunohistochemical expression of these proteins in PAS specimens in comparison with the control placental tissues.
• To correlate their expression with the demographic parameters.
• To assess the correlation between their expression in PAS specimens.

Enrollment: 60 patients

Sex: Female

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

inclusion criteria

• PAS patients who underwent hysterectomy to allow proper pathologic grading of PAS

exclusion criteria

• patients with fundal and middle anterior or posterior placenta,
• pregnancy associated with morbid conditions such as hypertension, diabetes mellitus, autoimmune disease, cardiac disease, renal disease, history of anemia, blood transfusion, other blood diseases and endocrinal disease; fetal distress or intrauterine growth retardation.
• uterine scar pregnancies were excluded

Trial design

60 participants in 2 patient groups

group A

Description:

30 placental specimens of PAS

Treatment:

Other: no intervention applied

group B

Description:

30 placental specimens of heaithy women with normal pregnancy

Treatment:

Other: no intervention applied