Impact of Neutrophil Activation in Acute Ischemic Stroke Patients Treated With Endovascular Therapy (NEUTROSTROKE)

Fondation Ophtalmologique Adolphe de Rothschild

Status: Active, not recruiting

Conditions: Acute Stroke

Study type: Observational

Funder types: NETWORK

Identifiers

NCT02900833

JDS_2015_46

Details and patient eligibility

About

Clinical and experimental data suggest that neutrophil activation and extravasation are deleterious in acute ischemic stroke (AIS) involving an increased risk of unfavorable outcome and hemorrhagic transformation (HT). However, clinical trials targeting neutrophil recruitment in AIS patients were negative. Recently, an experimental study has shown that neutrophil activation and transmigration begin immediately after the occlusion. Inhibition of neutrophil recruitment several hours after the start of ischemia appears therefore too late to have a clinical relevance.

The objective is to study the time dependent impact of neutrophils in AIS and the predominant mediators in each time point to identify the appropriate therapeutic target and time window.

Enrollment: 440 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age >= 18 years old
• acute ischemic stroke secondary to a large vessel occlusion.
• Patients hospitalized for endovascular therapy.

Exclusion criteria

• Pregnant or breast feeding patient
• patient under legal protection
• Patient opposition to participate in this study