Impact of Nimodipine on Sublingual Microcirculation in Patients With Hemorrhage - a Prospective Monocentric Observational Study

University Hospital Hradec Kralove

Status: Enrolling

Conditions: Subarachnoid Hemorrhage

Study type: Observational

Funder types: Other

Identifiers

NCT04311840

SAH_Nimodipine

Details and patient eligibility

About

Nimodipine can increase Functional Capillary Density (FCD) as a parameter of the sublingual microcirculation in patients with subarachnoid hemorrhage (SAH) compared to patients without nimodipine.

Full description

SAH group - in patients with SAH and documented vasospasms by digital subtraction angiography (DSA) of trans-cranial doppler imaging (TCD) of arteria cerebri media nimodipine is indicated because it is proven to improve the clinical outcome. The disfunction of cerebral microcirculation in rats with SAH has been documented [1-6]. Changes in sublingual microcirculation in patients with SAH with documented vasospasms with nimodipine has not been described.

Enrollment: 30 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• adulthood
• ICU admission
• diagnosis of non-traumatic subarachnoid hemorrhage

Exclusion criteria

• inherited coagulation disorder
• rheumatic disease
• microangiopathy
• patient of representative refusal

Trial design

30 participants in 2 patient groups

SAH patients with nimodipine

Description:

Patients with SAH receiving nimodipine as prevention of vasospasms and as a nootropic drug.

SAH patients without nimodipine

Description:

Patients with SAH not receiving nimodipine as prevention of vasospasms and as a nootropic drug or in whom the drug has been temporarily discontinued.