Impact of Nocturnal Hypoxemia on Glucose in High Altitude Sleep Disordered Breathing

Johns Hopkins University

Status

Begins enrollment in 5 months

Conditions

Sleep-Disordered Breathing

Glucose Intolerance

Treatments

Other: Compressed Air

Other: Supplemental Oxygen

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT05462834

IRB00329264

K23HL155730 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

Sleep disordered breathing is associated with impaired glucose tolerance and incident diabetes. Nocturnal hypoxemia is a potential stimulus of glucose intolerance. It is especially severe and highly prevalent in high altitude residents. Intervening on nocturnal hypoxemia may therefore improve glucose control and decrease the public health burden in high altitude populations.

The objective of this study is to examine the impact of hypoxemia on glucose homeostasis in high altitude residents. The investigators will address this objective by examining the effect of supplemental oxygen on glucose in a randomized cross-over study.

Enrollment

45 estimated patients

Sex

All

Ages

18 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Permanent residents of Puno, Peru

Exclusion criteria

Recent travel to low altitude (<3000 m)
Oxygen use
Pregnancy
Morbid obesity (BMI > 40 kg/m2)
Current smoking
Diabetes
Other sleep disorders (e.g. circadian rhythm disorder or insomnia)
Use of open fires in the home (i.e. for cooking or heat)
Chronic Mountain Sickness (CMS) as defined by a daytime oxyhemoglobin saturation < 85%, Qinghai CMS >10 or excessive erythrocytosis as defined by hemoglobin >19 g/dL in women or >21 g/dL in men.