Impact of Non Digestible Carbohydrate on Production of Phenolic Acids From Strawberry Juice

University of Glasgow

Status: Completed

Conditions: Healthy

Treatments: Dietary Supplement: Strawberry juice with Inulin; Dietary Supplement: Inulin; Dietary Supplement: Strawberry Juice

Study type: Interventional

Funder types: Other

Identifiers

NCT03383809

BB/MO27724/1-1

Details and patient eligibility

About

This is an acute human bioavailability study in self-reported healthy participants aged 20-70 years old. We hypothesize that combination of dietary polyphenolics and non-digestible carbohydrates (NDC) will increase the production of phenolic acids by bacteria in the human colon and these will be detected in urine. Participants will attend for three arms in a randomised order: Strawberry juice (a high polyphenol food), Inulin (NDC) or Mixture of strawberry juice and inulin.

Full description

Polyphenol rich plant foods have been associated with several health benefits but their bioavailability is generally low. The majority of plant polyphenols are poorly absorbed in the small intestine and enter the colon where the colonic microbiota metabolise them to release a range of phenolic acids, which are now thought to be the main bioactive components related to the reduction in disease risk. Very little is known about the impact of other constituents of the diet on the metabolism and bacterial catabolism of these polyphenols. The colonic microbiota are key agents in the release of the bioactive molecules from polyphenols but also ferment non-digestible carbohydrates (NDC) such as dietary fibre to short chain fatty acids. It is likely that there are key interactions in the colonic bacteria metabolism of fibre and phenolics. We hypothesize that combination of polyphenolics and non-digestible carbohydrates (NDC) will increase the urinary output of bioactive phenolic acids.

This study will enable a better understanding of how to deliver combinations of ingredients and nutrients to achieve maximum nutritional value and health benefits.

Enrollment: 15 patients

Sex: All

Ages: 20 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Self-reported healthy adults

Exclusion criteria

Antibiotic use within the last 3 months, identified gastro-intestinal diseases, on prescribed medication other than the contraceptive pill, individuals who are pregnant or breastfeeding. Individuals who have been diagnosed as anaemic, as well as those who are allergic to any food, or paracetamol.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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15 participants in 3 patient groups

Strawberry juice with inulin

Experimental group

Description:

One dose of 300 g of strawberry with 10 g of inulin will be given to subjects in the form of juice

Treatment:

Dietary Supplement: Strawberry juice with Inulin

Strawberry juice

Experimental group

Description:

One dose of 300 g of strawberry juice will be given to subjects in the form of juice

Treatment:

Dietary Supplement: Strawberry Juice

Inulin

Experimental group

Description:

One dose of 10 g of inulin will be given to subjects in the form of a drink

Treatment:

Dietary Supplement: Inulin