Impact of Non-glucose Signals on Glycemic Control in Patients With Type 1 Diabetes

Sansum Diabetes Research Institute

Status

Completed

Conditions

Type 1 Diabetes Mellitus

Treatments

Other: Observation During Exercise and Stress

Study type

Interventional

Funder types

Other

Identifiers

NCT03307850

JDRFSignals1

Details and patient eligibility

About

This clinical trial will identify exercise-related and emotional stress related effects on glycemic control in patients with type 1 diabetes using sensor-augmented pump (SAP) therapy.

Full description

Patients with type 1 diabetes (T1D) on an insulin pump will be studied for 5 weeks in the outpatient setting performing their normal activities, to include their normal diet and exercise, while assessing the amount of type of exercise performed, and emotional stress levels, using stress sensor, questionnaires and salivary cortisol levels.

Enrollment

20 patients

Sex

All

Ages

18 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age 18-75 years
Clinical diagnosis, based on investigator assessment, of T1D for at least one year and using insulin for at least 1 year.
Using an insulin pump for diabetes therapy for at least 3 months
Demonstration of proper mental status and cognition for the study
Non-smoker
If not currently using CGM, willing to use CGM during the study
An understanding of and willingness to follow the protocol and sign the informed consent

Exclusion criteria

Admission for diabetic ketoacidosis in the 6 months prior to enrollment unless study team feels the subject is appropriate for study given complete clinical context for subject
Severe hypoglycemia resulting in seizure or loss of consciousness > once in the 6 months prior to enrollment
History of a seizure disorder (except hypoglycemic seizure), unless written clearance is received from a neurologist and not currently on a seizure medication
Cystic fibrosis
Unstable coronary artery disease or heart failure, unless written clearance is received from a cardiologist or primary care provider
A known medical condition that in the judgment of the investigator might interfere with the completion of the protocol such as the following examples:
1. Inpatient psychiatric treatment in the past 6 months
2. Presence of a known adrenal disorder or chronic oral steroid therapy
3. Abnormal liver function test results (Transaminase >3 times the upper limit of normal); testing required for subjects taking medications known to affect liver function or with diseases known to affect liver function
4. Abnormal renal function test results (calculated GFR <60 mL/min/1.73m2);
5. Active gastroparesis (defined actively being treated with medications)
If on antihypertensive, thyroid, anti-depressant or lipid lowering medication, lack of stability on the medication for the past 2 months prior to enrollment in the study
Abuse of alcohol or recreational drugs
Pregnancy
Infectious process not anticipated to resolve prior to study procedures (e.g. meningitis, pneumonia, osteomyelitis).
Uncontrolled arterial hypertension (Resting diastolic blood pressure >90 mmHg and/or systolic blood pressure >160 mmHg) at the time of screening
Uncontrolled microvascular complications such as current active proliferative diabetic retinopathy defined as proliferative retinopathy requiring treatment (e.g. laser therapy) in the past 12 months.
A recent injury to body or limb, muscular disorder, use of any medication, any carcinogenic disease, or other significant medical disorder if that injury, medication or disease in the judgment of the investigator will affect the completion of the protocol.