Impact of Non-surgical Periodontal Treatment of miRNome

University of Catania

Status: Enrolling

Conditions: Periodontitis

Treatments: Other: Probin Pocket Depth reduction

Study type: Interventional

Funder types: Other

Identifiers

NCT06382935

34-24

Details and patient eligibility

About

A double-blind randomized-controlled clinical trial is conducted in order to evaluate the impact of non-surgical periodontal treatment by means of minimally invasive approach MINST or Q-SI (quadrantwise) approach in subjects with periodontitis on miRNome in gingival crevicular fluid

Full description

A double-blind randomized-controlled clinical trial is conducted in order to evaluate the impact of non-surgical periodontal treatment in subjects with periodontitis.

60 patients: 30 with periodontitis and 30 healthy controls. All the patients are assessed for clinical, periodontal, blood following of minimally invasive approach MINST or Q-SI (quadrantwise).

Measurements are taken before and after initial periodontal treatment in the periodontal subjects.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Diagnosis of Periodontitis

Exclusion criteria

• Periodontal treatment
• Use of antibiotics, NSAIDs, and immunosuppressants during the last 6 months
• Pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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60 participants in 2 patient groups

MINST non surgical periodontal treatment

Experimental group

Description:

Periodontitis patients treated by means of MINST. Patients were treated with non-surgical MINST periodontal treatment in a single session.

Treatment:

Other: Probin Pocket Depth reduction

Q-SI non surgical periodontal treatment

Active Comparator group

Description:

Periodontitis patients treated by means of Q-SI. Patients were treated with non-surgical quadrantwise periodontal treatment in 4 sessions, 1 session per week.

Treatment:

Other: Probin Pocket Depth reduction