Impact of OFA During LPV on Postoperative Oxygen Saturation

AZ Sint-Jan AV

Status: Completed

Conditions: Oxygen Requirement; Decreased Lung Compliance

Treatments: Procedure: opioid free anesthesia; Procedure: opioid anesthesia

Study type: Observational

Funder types: Other

Identifiers

NCT03660306

OS impact OFA on SAT d LPV

Details and patient eligibility

About

Opioids used intra operative increase the amount of opioids needed post operative to control post operative pain. if opioids are given post operative, we assume that more atelectasis and hypoxia takes place even after lung protective ventilation. These postoperative lower oxygen saturations will require giving more frequent oxygen therapy.

Full description

This is an observational study where the attending anesthesiologist decides to use opioid free or opioid general anesthesia based on his/her expertise.

Every patient gets a lung protective ventilation and emergence from anesthesia using the principles set forward in the consensus meeting by Young C BJA 2019.

A lung recruitment followed by high PEEP is given when lung compliance decreases below 40 ML/cmH20. The lowest oxygen saturation without adding oxygen therapy is noted post extubation at moment of admission in PACU, after having given an opioid as analgesic and at moment of discharge from PACU..

If post operative satuation drops below 94% oxygen therapy is given and noted.

Enrollment: 64 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• major surgery where intubation with mechanical ventilation is required
• obese patients with BMI > 35

Exclusion criteria

• spontaneous breathing during procedure
• allergic to any of the drugs used in both groups
• severe liver, renal, cardiac or pulmonary disease

Trial design

64 participants in 2 patient groups

opioid anesthesia

Description:

classical anesthesia using sufentanil to block sympathetic reactions during surgery. This decision is based on the anesthesiologist experience and not determined by the patient or procedure.

Treatment:

Procedure: opioid anesthesia

opioid free anesthesia

Description:

anesthesia using non opioids like dexmedetomidine, lidocaine, magnesium and ketamine to block sympathetic reactions during surgery. This decision is based on the anesthesiologist experience and not determined by the patient or procedure.

Treatment:

Procedure: opioid free anesthesia