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Impact of Olfactory Odour StimulatioN on Energy EXpenditure (SNEEX)

University Hospital Basel logo

University Hospital Basel

Status

Enrolling

Conditions

Obesity

Treatments

Other: Olfactory Stimulation

Study type

Interventional

Funder types

Other

Identifiers

NCT05472168
Timper_Olfactory_2022

Details and patient eligibility

About

In this preliminary short-term study it is investigated, whether a short olfactory stimulation with distinct odours impacts energy expenditure in patients with obesity and lean patients.

Enrollment

58 estimated patients

Sex

All

Ages

18 to 55 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • • Age 18-55 years

    • Obesity (BMI ≥30 kg/m2) and Lean (BMI 18-25 kg/m2)
    • Written informed consent
    • Normosmia (defined by sniffing Sticks test)

Exclusion criteria

  • • Chronic or acute sinusitis

    • Surgical intervention of the nasal cavity or the paranasal sinus
    • Known allergy to odors used in the study
    • Smokers
    • Current illicit drug abuse including daily marijuana and cannabidiol (CBD) consumption (alcohol ≤2 drinks per day allowed)
    • Any kind of severe chronic disease (e.g. severe heart failure, active cancer disease)
    • Diabetes mellitus
    • Treatment with insulin sensitizing drugs including Glucagon-like Peptide (GLP)-1 analogues within the last 3 months
    • History of neurodegenerative diseases, severe head trauma
    • Severe renal impairment (e.g. estimated glomerular filtration rate <30 ml/min/m2)
    • Known liver cirrhosis or other severe liver impairment
    • Use of any kind of decongestant more than twice a week
    • Use of cortisone-containing nasal spray within the last 3 months
    • Acute upper respiratory tract infection
    • Uncontrolled dysthyroidism
    • Uncontrolled hypertension
    • Regular use of psychopharmaceutic drugs
    • Study participants aims to start a new diet or exercise program during the study
    • Bariatric surgery
    • Pregnancy/Lactation
    • Onset of climacteric symptoms within one year (e.g. hot flashes and/or diaphoresis) OR initiation of hormonal replacement therapy in the last three months
    • Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc.
    • Participation in an interventional study within the last 3 months

Trial design

Primary purpose

Other

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

Single Blind

58 participants in 2 patient groups

Obese
Other group
Description:
Age 18-55 years Obesity (BMI ≥30 kg/m2) Written informed consent Normosmia (defined by sniffing Sticks test)
Treatment:
Other: Olfactory Stimulation
Lean
Other group
Description:
Age 18-55 years Lean (BMI 18-25 kg/m2) Written informed consent Normosmia (defined by sniffing Sticks test)
Treatment:
Other: Olfactory Stimulation

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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