Impact of Opportunistic Salpingectomy on Ovarian Reserve in Patients Undergoing Laparoscopic Hysterectomy

CHA University

Status and phase

Completed

Phase 3

Conditions

Benign Uterine Disease

Treatments

Procedure: LH with opportunistic salpingectomy

Procedure: LH alone

Study type

Interventional

Funder types

Other

Identifiers

NCT01893086

KNC13-029

Details and patient eligibility

About

Recently, many gynecologic oncologists proposed that surgeons should consider opportunistic salpingectomy to prevent ovarian cancer for all patients undergoing hysterectomy for benign disease. However, the safety and the consequences regarding ovarian function after salpingectomy have not yet to be established. Therefore, the aim of this randomized controlled study is compare the ovarian reserve via anti-Müllerian hormone (AMH) between laparoscopic hysterectomy (LH) alone and LH combined with salpingectomy.

Enrollment

68 patients

Sex

Female

Ages

19 to 52 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

women who were planning to undergo laparoscopic hysterectomy for benign uterine diseases
women aged between 19 and 52 years
women with regular menstruation (defined as the duration of menstrual cycle between 21 and 45 days)
women who were appropriated medical status for laparoscopic surgery

Exclusion criteria

any ovarian cysts requiring ovarian surgery
any suspicious findings of malignant diseases
history of prior salpingectomy or salpingo-oophorectomy
pregnant or menopausal status
preoperative serum anti-Müllerian hormone (AMH) < 0.30 ng/mL
use of hormonal treatments in the three months before surgery
any other endocrine disease (such as uncontrolled thyroid dysfunction, hyperprolactinemia, or Cushing syndrome)
an inability to understand and provide written informed consent.