Impact of Parathyroidectomy on Cardiovascular Calcification in Dialysis-dependent Patients

Saint Petersburg State University, Russia

Status: Completed

Conditions: Dialysis; Vascular Calcification; Secondary Hyperparathyroidism; Chronic Kidney Disease Mineral and Bone Disorder

Study type: Observational

Funder types: Other

Identifiers

NCT03937349

Calcification

Details and patient eligibility

About

This is a prospective cohort study aimed to evaluate change of cardiovascular calcification after parathyroidectomy in patients with end-stage renal disease on dialysis compared with control group on conservative treatment.

Enrollment: 63 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age > 18 years
2. ESRD patients receiving long-term hemodialysis or peritoneal dialysis treatment
3. Severe secondary hyperparathyroidism defined as iPTH level > 800 pg/ml, followed with hypercalcemia and/or hyperphosphatemia; with presence of one or more nodular or diffuse parathyroid hyperplasia confirmed with CT

Exclusion criteria

1. Primary hyperparathyroidosis as a cause of ESRD

Trial design

63 participants in 3 patient groups

sPTx group

Description:

Patients underwent subtotal parathyroidectomy due to severe secondary hyperparathyroidism

TPTx+AT group

Description:

Patients underwent total parathyroidectomy with immediate autotransplantation of parathyroid tissue due to severe secondary hyperparathyroidism

Control group

Description:

Patients with severe SHPT on conservative treatment (calcimimetics, active vitamin D analogues, phosphate-binders) who are likely to undergo surgery in a period of 12 months