Impact of Periodontal Treatment on Gastric Helicobacter Pylori Eradication

Ondokuz Mayıs University

Status and phase: Completed; Phase 1

Conditions: Helicobacter Pylori Infection

Treatments: Drug: Triple therapy; Procedure: professional periodontal treatment

Study type: Interventional

Funder types: Other

Identifiers

NCT03654781

OMUetik 2009/95 (Other Identifier)

OndokusMU1

Details and patient eligibility

About

The efficacy of conventional systemic antibiotic therapy for eradication of gastric H. pylori has been seriously challenged by antibiotic resistance. Identification of alternative therapeutic strategies might help to overcome the limitation. The investigators' aim was to examine the effect of adjunct periodontal therapy, on gastric H. pylori eradication rate.

Enrollment: 98 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• tested positive for H. pylori both in gastric biopsy specimens and dental plaque samples

Exclusion criteria

The patients who had treatment with following medications within 6 months before the clinical protocol:

• had antibiotics
• had Proton pump inhibitor (PPI),
• had H2 blockers, and
• took bismuth derivatives
• had previous eradication therapy, or
• had previous periodontal therapy
• Edentulous patient
• Diabetic patients
• pregnant patients

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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98 participants in 2 patient groups

Triple therapy

Active Comparator group

Description:

Conventional triple antibiotic treatment would be applied to all patients (consisted of a 10-day course of Lansoprazole (a proton pump inhibitor) combined with amoxicillin ( 2 × 1 g daily) and clarithromycin (2 × 500 mg daily).

Treatment:

Drug: Triple therapy

Combined treatment

Experimental group

Description:

Periodontal treatment would be administered in addition to triple therapy consisted of a 10-day course of a Lansoprazole (proton pump inhibitor )combined with amoxicillin (2 × 1 g daily) and clarithromycin (2 × 500 mg daily). Periodontal treatment consisted of supra and sub gingival scaling and root planing, oral hygiene instruction

Treatment:

Procedure: professional periodontal treatment

Drug: Triple therapy